In the absence of treatment for infection, children have a much higher risk of progression to a severe and fatal form of the disease. This risk is highest in children who are young and malnourished, or have a weakened immune system from other diseases or infections, such as HIV. Treatment outcomes are best when tuberculosis is diagnosed early. Our research team is working to identify rapid, simple, and inexpensive tools that support accurate diagnosis of TB disease in children. We are also engaged in discovery work to identify biomarkers correlating progression from the initial exposure to infection and the infection to disease.